Article
BLM promotes the activation of Fanconi Anemia signaling pathway.
Oncotarget - 31 May 2016
Panneerselvam Jayabal, Wang Hong, Zhang Jun, Che Raymond, Yu Herbert, Fei Peiwen
Abstract excerpt
Mutations in the human RecQ helicase, BLM, causes Bloom Syndrome, which is a rare autosomal recessive disorder and characterized by genomic instability and an increased risk of cancer. Fanconi Anemia (FA), resulting from mutations in any of the 19 known FA genes and those yet to be known, is also characterized by chromosomal instability and a high incidence of cancer. BLM helicase and FA proteins, therefore, may...
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