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Article

S-nitrosylation of ERK inhibits ERK phosphorylation and induces apoptosis.

Scientific reports - 1 Jan 2013

Feng Xiujing, Sun Tingzhe, Bei Yuncheng, Ding Sen, Zheng Wei, Lu Yan, Shen Pingping

Abstract excerpt

Extracellular signal-regulated kinase (ERK) belongs to the mitogen-activated protein kinases (MAPK) superfamily. Aberrant upregulation and activation of ERK cascades may often lead to tumor cell development. However, how ERK is involved in tumor progression is yet to be defined. In current study, we described that ERK undergoes S-nitrosylation by nitric oxide (NO). ERK S-nitrosylation inhibits its phosphorylation...

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Identifiers

PMID: 23657295
DOI: 10.1038/srep01814
PMCID: PMC3648801

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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