Article
S-nitrosylation of the death receptor fas promotes fas ligand-mediated apoptosis in cancer cells.
Gastroenterology - 1 Jun 2011
Leon-Bollotte Lissbeth, Subramaniam Selvakumar, Cauvard Olivier, Plenchette-Colas Stéphanie, Paul Catherine, Godard Cindy, Martinez-Ruiz Antonio, Legembre Patrick, Jeannin Jean-François, Bettaieb Ali
Abstract excerpt
BACKGROUND & AIMS: Fas belongs to the family of tumor necrosis factor receptors which induce apoptosis. Many cancer cells express Fas but do not undergo Fas-mediated apoptosis. Nitric oxide reverses this resistance by increasing levels of Fas at the plasma membrane. We studied the mechanisms by which NO affects Fas function. METHODS: Colon and mammary cancer cell lines were incubated with the NO donor glyceryl...
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