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Article

S-Nitrosylation of the epidermal growth factor receptor: a regulatory mechanism of receptor tyrosine kinase activity.

Free radical biology & medicine - 15 Feb 2009

Murillo-Carretero Maribel, Torroglosa Ana, Castro Carmen, Villalobo Antonio, Estrada Carmen

Abstract excerpt

Nitric oxide (NO) donors inhibit the epidermal growth factor (EGF)-dependent auto(trans)phosphorylation of the EGF receptor (EGFR) in several cell types in which NO exerts antiproliferative effects. We demonstrate in this report that NO inhibits, whereas NO synthase inhibition potentiates, the EGFR tyrosine kinase activity in NO-producing cells, indicating that physiological concentrations of NO were able to...

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Identifiers

PMID: 19056486
DOI: 10.1016/j.freeradbiomed.2008.10.048

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EGFR
EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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