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Article

S-nitrosylation at cysteine 498 of c-Src tyrosine kinase regulates nitric oxide-mediated cell invasion.

The Journal of biological chemistry - 5 Feb 2010

Rahman Mohammad Aminur, Senga Takeshi, Ito Satoko, Hyodo Toshinori, Hasegawa Hitoki, Hamaguchi Michinari

Abstract excerpt

Nitric oxide (NO) plays a pivotal role in tumorigenesis, particularly with relation to cancer cell invasion and metastasis. NO can reversibly couple to cysteine thiols to form an S-nitrosothiol, which regulates the enzymatic activities of target proteins. c-Src is a tyrosine kinase that promotes cancer cell invasion and metastasis. Interestingly, c-Src can be activated by NO stimulation. However, mechanisms by...

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Identifiers

PMID: 19948721
DOI: 10.1074/jbc.M109.059782
PMCID: PMC2823522

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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