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Article

Dual potential of extracellular signal-regulated kinase for the control of cell survival.

Biochemical and biophysical research communications - 2 Nov 1999

Ishikawa Y, Kitamura M

Abstract excerpt

Extracellular signal-regulated kinase (ERK) controls cell proliferation positively or negatively depending on the cellular contexts in which ERK is activated. In this report, we address differential roles of transient and constitutive activation of ERK in cell survival. Under a basal culture condition, mesangial cells showed modest, sustained ERK activity. The activity of ERK was transiently upregulated (15-60...

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Identifiers

PMID: 10543994
DOI: 10.1006/bbrc.1999.1542

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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