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Circulating myeloid cells invade the central nervous system to mediate cachexia during pancreatic cancer

11 May 2020

Abstract excerpt

Weight loss and anorexia are common symptoms in cancer patients that occur prior to initiation of cancer therapy. Inflammation in the brain is a driver of these symptoms, yet cellular sources of neuroinflammation during malignancy are unknown. In a mouse model of pancreatic ductal adenocarcinoma (PDAC), we observed early and robust myeloid cell infiltration into the brain. Infiltrating immune cells were...

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PMID: 32391790
DOI: 10.7554/elife.54095

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