Article
Rapid improvement of hepatic steatosis after initiation of leptin substitution in a leptin-deficient girl.
Hormone research in paediatrics - 1 Jan 2013
von Schnurbein J, Heni M, Moss A, Nagel S A, Machann J, Muehleder H, Debatin K M, Farooqi S, Wabitsch M
Abstract excerpt
BACKGROUND: Leptin deficiency is associated with severe obesity and metabolic disturbances. Increased liver fat content has been reported in only one case beforehand, even though hepatic steatosis is a typical comorbidity of common obesity. It is also frequent in patients with lipodystrophy where it resolves under leptin therapy. SUBJECT AND METHODS: In 2010, we reported a leptin-deficient patient with a novel...
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