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Metreleptin Improves Blood Glucose in Patients With Insulin Receptor Mutations

23 Aug 2013

Abstract excerpt

CONTEXT: Rabson-Mendenhall syndrome (RMS) is caused by mutations of the insulin receptor and results in extreme insulin resistance and dysglycemia. Hyperglycemia in RMS is very difficult to treat, and patients are at risk for early morbidity and mortality from complications of diabetes. OBJECTIVE: Our objective was to study 1-year effects of recombinant human methionyl leptin (metreleptin) in 5 patients with RMS...

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PMID: 23969187
DOI: 10.1210/jc.2013-2317

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