Article
A cutaneous gene therapy approach to human leptin deficiencies: correction of the murine ob/ob phenotype using leptin-targeted keratinocyte grafts.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 2001
Larcher F, Del Rio M, Serrano F, Segovia J C, Ramírez A, Meana A, Page A, Abad J L, González M A, Bueren J, Bernad A, Jorcano J L
Abstract excerpt
Leptin deficiency produces a phenotype of obesity, diabetes, and infertility in the ob/ob mouse. In humans, leptin deficiency occurs in some cases of congenital obesity and in lipodystrophic disorders characterized by reduced adipose tissue and insulin resistance. Cutaneous gene therapy is considered an attractive potential method to correct circulating protein deficiencies, since gene-transferred human...
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