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Article

Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults.

Proceedings of the National Academy of Sciences of the United States of America - 30 Mar 2004

Licinio Julio, Caglayan Sinan, Ozata Metin, Yildiz Bulent O, de Miranda Patricia B, O'Kirwan Fiona, Whitby Robert, Liang Liyin, Cohen Pinchas, Bhasin Shalender, Krauss Ronald M, Veldhuis Johannes D, Wagner Anthony J, DePaoli Alex M, McCann Samuel M, Wong Ma-Li

Abstract excerpt

Genetic mutations in the leptin pathway can be a cause of human obesity. It is still unknown whether leptin can be effective in the treatment of fully established morbid obesity and its endocrine and metabolic consequences in adults. To test the hypothesis that leptin has a key role in metabolic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15070752
DOI: 10.1073/pnas.0308767101
PMCID: PMC384781

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15070752-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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