Article
Selective capacity of metreleptin administration to reconstitute CD4+ T-cell number in females with acquired hypoleptinemia.
Proceedings of the National Academy of Sciences of the United States of America - 26 Feb 2013
Matarese Giuseppe, La Rocca Claudia, Moon Hyun-Seuk, Huh Joo Young, Brinkoetter Mary T, Chou Sharon, Perna Francesco, Greco Dario, Kilim Holly P, Gao Chuanyun, Arampatzi Kalliope, Wang Zhaoxi, Mantzoros Christos S
Abstract excerpt
Leptin is an adipocyte-derived hormone that controls food intake and reproductive and immune functions in rodents. In uncontrolled human studies, low leptin levels are associated with impaired immune responses and reduced T-cell counts; however, the effects of leptin replacement on the adaptive immune system have not yet been reported in the context of randomized, controlled studies and/or in conditions of...
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