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Article

Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency

16 Sept 1999

Abstract excerpt

Severely obese (ob/ob) mice are deficient in the adipocyte-derived hormone leptin, which acts on the hypothalamus to control appetite and energy expenditure.1 The administration of leptin to these mice corrects their obesity by reducing their food intake and increasing their energy expenditure.2–4 These mice also have hyperinsulinemia, corticosterone excess, and infertility, which also are reversed by treatment...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 10486419
DOI: 10.1056/nejm199909163411204

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