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Article

Congenital leptin deficiency: diagnosis and effects of leptin replacement therapy.

Arquivos brasileiros de endocrinologia e metabologia - 1 Nov 2010

Paz-Filho Gilberto, Mastronardi Claudio, Delibasi Tuncay, Wong Ma-Li, Licinio Julio

Abstract excerpt

To describe our 10-year experience in treating leptin-deficient humans. Three adults and one boy presented with childhood-onset morbid obesity, hypogonadism and family history of obesity and early death. Serum leptin was inappropriately low. A recessive C105T leptin gene mutation was identified. Metabolic and endocrine assessments were conducted, before and while on and off leptin. The adults' body mass index...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21340154
DOI: 10.1590/s0004-27302010000800005
PMCID: PMC4286252

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