Article
Determination of amino acids critical to the main immunogenic region of intact acetylcholine receptors by in vitro mutagenesis.
FEBS letters - 2 Jul 1990
Saedi M S, Anand R, Conroy W G, Lindstrom J
Abstract excerpt
The main immunogenic region (MIR) of the acetylcholine receptor (AChR) is the target for the majority of high-affinity autoantibodies produced in myasthenia gravis patients. Some monoclonal antibodies (mAbs) to the MIR bind specifically, but with low affinity, to synthetic AChR alpha subunit peptides with the sequence alpha 67-76. Studies of synthetic peptides suggest that amino acids alpha 68 and alpha 71 may be...
Topics
- Amino Acids
- Animals
- Antibodies, Monoclonal
- Antigens
- Humans
- In Vitro Techniques
- Mutation
- Myasthenia Gravis
- Oocytes
- Protein Conformation
- Receptors, Cholinergic