Article
Early-onset myasthenia gravis: a recurring T-cell epitope in the adult-specific acetylcholine receptor epsilon subunit presented by the susceptibility allele HLA-DR52a.
Annals of neurology - 1 Feb 1999
Hill M, Beeson D, Moss P, Jacobson L, Bond A, Corlett L, Newsom-Davis J, Vincent A, Willcox N
Abstract excerpt
No immunodominant T-cell epitopes have yet been reported in the human acetylcholine receptor (AChR), the target of the pathogenic autoantibodies in myasthenia gravis (MG). We have selected and characterized T cells from MG patients by restimulation in culture with recombinant human AChR to alpha, gamma and epsilon subunits; the gamma and epsilon distinguish the fetal and adult AChR isoforms, respectively. We...
Topics
- Amino Acid Sequence
- Base Sequence
- Epitopes, T-Lymphocyte
- Humans
- Molecular Sequence Data
- Myasthenia Gravis
- Phenotype
- Receptors, Antigen, T-Cell
- Receptors, Cholinergic
- Time Factors