Article
Characterization of human anti-acetylcholine receptor monoclonal autoantibodies from the peripheral blood of a myasthenia gravis patient using combinatorial libraries.
Clinical immunology (Orlando, Fla.) - 1 Sept 2000
Rey E, Zeidel M, Rhine C, Tami J, Krolick K, Fischbach M, Sanz I
Abstract excerpt
Myasthenia gravis (MG) is an autoimmune disease caused by autoantibodies against the nicotinic acetylcholine receptor (AChR). Using phage-display technology we have characterized the largest panel of anti-AChR monoclonal antibodies thus far isolated from a single patient. Despite having been isolated with either Torpedo AChR or a human peptide, the recombinant antibodies shared with the donor's serum the ability...
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