Article
Suppression of experimental autoimmune myasthenia gravis by epitope-specific neonatal tolerance to synthetic region alpha 146-162 of acetylcholine receptor.
Clinical immunology and immunopathology - 1 Mar 1993
Shenoy M, Oshima M, Atassi M Z, Christadoss P
Abstract excerpt
A gene conversion event between Ebb and Abb in the B6.C-H-2bm12 (bm12) strain, which alters three amino acids in the C-terminal half of the first domain of Abb (Ile-67-->Phe; Arg-70-->Gln; Thr-71-->Lys) resulted in resistance to experimental autoimmune myasthenia gravis (EAMG) pathogenesis. To study the effect of bm12 mutation on the T-cell responses to epitopes of acetylcholine receptor (AChR)-alpha subunit,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.