Article
The I-Abm12 mutation, which confers resistance to experimental myasthenia gravis, drastically affects the epitope repertoire of murine CD4+ cells sensitized to nicotinic acetylcholine receptor.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 1991
Bellone M, Ostlie N, Lei S J, Wu X D, Conti-Tronconi B M
Abstract excerpt
Susceptibility to experimental autoimmune myasthenia gravis (EAMG), which is induced in mice by injection of purified Torpedo nicotinic acetylcholine receptor (TAChR), is influenced by the I-A locus products, which restrict presentation of AChR Th epitopes. The bm12 mutation of the I-Ab molecule in the C57BL/6 strain, which is highly susceptible to EAMG, yields the EAMG resistant mutant B6.C-H-2bm12 (bm12). We...
Topics
- Animals
- Antibodies
- Antigen-Presenting Cells
- CD4 Antigens
- Cross Reactions
- Epitopes
- Female
- Histocompatibility Antigens Class II
- Mice
- Mice, Inbred C57BL