Article
Mechanisms by which the I-ABM12 mutation influences susceptibility to experimental myasthenia gravis: a study in homozygous and heterozygous mice.
Scandinavian journal of immunology - 1 Aug 1995
Karachunski P I, Ostlie N, Bellone M, Infante A J, Conti-Fine B M
Abstract excerpt
The I-Abm12 mutation in C57B1/6 (B6) mice yields the B6.C-H-2bm12 (bm12) strain, which is resistant to Experimental Myasthenia Gravis (EMG) induced by immunization with Torpedo acetylcholine receptor (TAChR), while the parental B6 strain is highly susceptible to EMG. CD4+ cells from bm12 mice imm...
Topics
- Animals
- Antigen Presentation
- CD4-Positive T-Lymphocytes
- Haplotypes
- Heterozygote
- Histocompatibility Antigens Class II
- Homozygote
- Mice
- Mice, Inbred C57BL
- Mutation
- Myasthenia Gravis
- Receptors, Cholinergic
- Torpedo