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Article

Characterization of mutants of influenza A virus selected with the neuraminidase inhibitor 4-guanidino-Neu5Ac2en.

Journal of virology - 1 Mar 1996

Gubareva L V, Bethell R, Hart G J, Murti K G, Penn C R, Webster R G

Abstract excerpt

The development of viral resistance to the neuraminidase (NA) inhibitor, 4-guanidino-Neu5Ac2en, of influenza viruses was studied by serial passage of A/Turkey/Minnesota/833/80 (H4N2) in Madin-Darby canine kidney cells in the presence of increasing concentrations of inhibitor. Resistant mutants selected after eight passages, had a 10,000-fold reduction in sensitivity to the inhibitor in plaque assays, but their...

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Identifiers

PMID: 8627706
DOI: 10.1128/JVI.70.3.1818-1827.1996
PMCID: PMC190009

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