Article
Generation and characterization of a mutant of influenza A virus selected with the neuraminidase inhibitor BCX-140.
Antimicrobial agents and chemotherapy - 1 Apr 1998
Bantia S, Ghate A A, Ananth S L, Babu Y S, Air G M, Walsh G M
Abstract excerpt
Influenza neuraminidase (NA) plays an important role in viral replication, and characterization of viruses resistant to NA inhibitors will help elucidate the role of active-site residues. This information will assist in designing better inhibitors targeted to essential active-site residues that c...
Topics
- Animals
- Benzoates
- Cell Line
- Coloring Agents
- Dogs
- Drug Resistance, Microbial
- Enzyme Inhibitors
- Erythrocytes
- Hemagglutinins
- Humans
- Influenza A virus
- Mutation
- Neuraminidase
- Phenotype
- Tetrazolium Salts
- Thiazoles
- Viral Plaque Assay
- Virus Replication