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Article

Generation and characterization of a mutant of influenza A virus selected with the neuraminidase inhibitor BCX-140.

Antimicrobial agents and chemotherapy - 1 Apr 1998

Bantia S, Ghate A A, Ananth S L, Babu Y S, Air G M, Walsh G M

Abstract excerpt

Influenza neuraminidase (NA) plays an important role in viral replication, and characterization of viruses resistant to NA inhibitors will help elucidate the role of active-site residues. This information will assist in designing better inhibitors targeted to essential active-site residues that cannot generate drug-resistant mutations. In the present study we used the benzoic acid-based inhibitor BCX-140 to...

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Identifiers

PMID: 9559786
DOI: 10.1128/AAC.42.4.801
PMCID: PMC105545

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