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Article

Enzymatic detoxication, conformational selection, and the role of molten globule active sites.

The Journal of biological chemistry - 21 Jun 2013

Honaker Matthew T, Acchione Mauro, Zhang Wei, Mannervik Bengt, Atkins William M

Abstract excerpt

The role of conformational ensembles in enzymatic reactions remains unclear. Discussion concerning "induced fit" versus "conformational selection" has, however, ignored detoxication enzymes, which exhibit catalytic promiscuity. These enzymes dominate drug metabolism and determine drug-drug interactions. The detoxication enzyme glutathione transferase A1-1 (GSTA1-1), exploits a molten globule-like active site to...

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Source

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Identifiers

PMID: 23649628
DOI: 10.1074/jbc.M112.445767
PMCID: PMC3689999

Genes

GSTA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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