Article
Template-directed protein folding into a metastable state of increased activity.
European journal of biochemistry - 1 Sept 1995
Flecker P
Abstract excerpt
The principal objective of this work was to distinguish between kinetic and thermodynamic reaction control in protein folding. The deleterious effects of a specific mutation on spontaneous refolding competence were analyzed for this purpose. A Bowman-Birk-type proteinase inhibitor of trypsin and chymotrypsin was selected as a double-headed model protein to facilitate the detection of functional irregularities by...
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