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Article

The free energy landscape in translational science: how can somatic mutations result in constitutive oncogenic activation?

Physical chemistry chemical physics : PCCP - 14 Apr 2014

Tsai Chung-Jung, Nussinov Ruth

Abstract excerpt

The free energy landscape theory has transformed the field of protein folding. The significance of perceiving function in terms of conformational heterogeneity is gradually shifting the interest in the community from folding to function. From the free energy landscape standpoint the principles are unchanged: rather than considering the entire protein conformational landscape, the focus is on the ensemble around...

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Identifiers

PMID: 24445437
DOI: 10.1039/c3cp54253j
PMCID: PMC7667491

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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