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High-Throughput Screening of Inhibitors Targeting<i>Agr</i>/<i>Fsr</i>Quorum Sensing in<i>Staphylococcus aureus</i>and<i>Enterococcus faecalis</i>

6 May 2013

Abstract excerpt

Staphylococcus aureus and Enterococcus faecalis employ cyclic peptide-mediated quorum sensing (QS) systems, termed agr and fsr respectively, to regulate the expression of a series of virulence genes. To identify quorum sensing inhibitors (QSIs) that target agr/fsr systems, an efficient screening system was established. In addition to the gelatinase-induction assay to examine E. faecalis fsr QS, the use of an S....

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PMID: 23649251
DOI: 10.1271/bbb.120769

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