Article
Selective chemical inhibition of agr quorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistance.
PLoS pathogens - 1 Jun 2014
Sully Erin K, Malachowa Natalia, Elmore Bradley O, Alexander Susan M, Femling Jon K, Gray Brian M, DeLeo Frank R, Otto Michael, Cheung Ambrose L, Edwards Bruce S, Sklar Larry A, Horswill Alexander R, Hall Pamela R, Gresham Hattie D
Abstract excerpt
Bacterial signaling systems are prime drug targets for combating the global health threat of antibiotic resistant bacterial infections including those caused by Staphylococcus aureus. S. aureus is the primary cause of acute bacterial skin and soft tissue infections (SSTIs) and the quorum sensing operon agr is causally associated with these. Whether efficacious chemical inhibitors of agr signaling can be developed...
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