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Linear peptidomimetics as potent antagonists of Staphylococcus aureus agr quorum sensing

19 Feb 2018

Abstract excerpt

Staphylococcus aureus is an important pathogen causing infections in humans and animals. Increasing problems with antimicrobial resistance has prompted the development of alternative treatment strategies, including antivirulence approaches targeting virulence regulation such as the agr quorum sensing system. agr is naturally induced by cyclic auto-inducing peptides (AIPs) binding to the AgrC receptor and cyclic...

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PMID: 29476092
DOI: 10.1038/s41598-018-21951-4

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