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Drug-like Fragments Inhibit agr-Mediated Virulence Expression in Staphylococcus aureus

1 May 2019

Abstract excerpt

In response to the increasingly problematic emergence of antibiotic resistance, novel strategies for combating pathogenic bacteria are being investigated. Targeting the agr quorum sensing system, which regulates expression of virulence in Staphylococcus aureus, is one potentially useful approach for combating drug-resistant pathogens that has not yet been fully explored. A previously published study of a fragment...

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PMID: 31043623
DOI: 10.1038/s41598-019-42853-z

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