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Article

Phenotypic and functional alterations of primary human PBMCs induced by HCV non-enveloped capsid-like particles uptake.

Cellular and molecular life sciences : CMLS - 1 Sept 2013

Doumba Polyxeni P, Serti Elisavet, Boutsikou Maria, Konstadoulakis Manousos M, Georgopoulou Urania, Koskinas John

Abstract excerpt

Hepatitis C virus non-enveloped particles circulate in the serum of HCV-infected patients and are believed to be involved in viral persistence. It was previously demonstrated that recombinant HCVne particles can efficiently enter T cells. In this study we investigated the effect of this entry on the phenotype and function of PBMCs, focused on the CD4+ and CD8+ T-cells. We have generated recombinant HCVne in the...

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Identifiers

PMID: 23645326
DOI: 10.1007/s00018-013-1344-y
PMCID: PMC11113332

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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