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Article

Exhausted phenotype of circulating CD8+ T cell subsets in hepatitis B virus carriers.

BMC immunology - 20 Apr 2022

Jiang Daixi, Chen Can, Yan Danying, Zhang Xiaobao, Liu Xiaoxiao, Yan Dong, Cui Dawei, Yang Shigui

Abstract excerpt

BACKGROUND: Chronic hepatitis B virus (HBV) infection is characterized by the presence of dysfunctional exhausted CD8+ T cells that hamper viral control. We investigated the phenotypic heterogeneity of exhausted CD8+ T cells in HBV carriers. METHODS: We enrolled 31 HBV carriers and 23 healthy controls (HCs) in our study. Peripheral blood mononuclear cells (PBMCs) were isolated, and flow cytometry was used to...

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Identifiers

PMID: 35443611
DOI: 10.1186/s12865-022-00488-2
PMCID: PMC9022260

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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