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Article

Proteomics reveals a global phenotypic shift of NK cells in HCV patients treated with direct-acting antivirals.

European journal of immunology - 1 Nov 2023

Bi Wenjie, Kraft Anke, Engelskircher Sophie, Mischke Jasmin, Witte Moana, Klawonn Frank, van Ham Marco, Cornberg Markus, Wedemeyer Heiner, Hengst Julia, Jänsch Lothar

Abstract excerpt

Chronic hepatitis C virus (HCV) infections compromise natural killer (NK)-cell immunity. Direct-acting antivirals (DAA) effectively eliminate HCV, but the long-term effects on NK cells in cured patients are debated. We conducted a proteomic study on CD56+ NK cells of chronic HCV-infected patients before and 1 year after DAA therapy. Donor-variation was observed in NK-cell proteomes of HCV-infected patients, with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37515498
DOI: 10.1002/eji.202250291

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