Influence of survivin (BIRC5) and caspase-9 (CASP9) functional polymorphisms in renal cell carcinoma development: a study in a southern European population.

doi:10.1007/s11033-013-2578-3

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Article

Influence of survivin (BIRC5) and caspase-9 (CASP9) functional polymorphisms in renal cell carcinoma development: a study in a southern European population.

Molecular biology reports - 1 Aug 2013

Marques Inês, Teixeira Ana L, Ferreira Marta, Assis Joana, Lobo Francisco, Maurício Joaquina, Medeiros Rui

Abstract excerpt

Renal cell carcinoma (RCC) is the most common cancer of the adult kidney and its incidence and mortality has increase in the last 20 years. The disruption of cellular death is one the mechanism involved in cancer development. This process is precise regulated by apoptotic and anti-apoptotic molecules. Survivin (BIRC5) is a member of the inhibitor of apoptosis protein family and has the ability to inhibit the...

Topics

Aged
Apoptosis
Carcinoma, Renal Cell
Caspase 9
Female
Genetic Predisposition to Disease
Genotype
Humans
Inhibitor of Apoptosis Proteins
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Metastasis

Odds Ratio

Polymorphism, Restriction Fragment Length

Polymorphism, Single Nucleotide

Portugal

Proportional Hazards Models

Real-Time Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 23645041
DOI: 10.1007/s11033-013-2578-3

Genes

CASP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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