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Article

The CASP8 -652 6N insertion/deletion promoter polymorphism is associated with renal cell carcinoma risk and metastasis.

The Journal of urology - 1 Aug 2013

de Martino Michela, Haitel Andrea, Schatzl Georg, Klingler Hans Christoph, Klatte Tobias

Abstract excerpt

PURPOSE: Caspase-8 is a key regulator of apoptosis. Its cancer cell antigen induced cell death activity is strongly impacted by the insertion/deletion promoter polymorphism CASP8 -652 6N ins/del (rs3834129). We studied the association of this polymorphism with renal cell carcinoma risk and pathology. MATERIALS AND METHODS: In this hospital based case-control study 500 Austrian patients were genotyped, including...

Topics

Alleles
Apoptosis
Austria
Carcinoma, Renal Cell
Case-Control Studies
Caspase 8
Chi-Square Distribution
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Genotype

Humans

Kidney Neoplasms

Logistic Models

Male

Middle Aged

Mutagenesis, Insertional

Neoplasm Grading

Neoplasm Metastasis

Source

Identifiers

PMID: 23313206
DOI: 10.1016/j.juro.2013.01.008

Genes

CASP8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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