Article
A genetic variant in pre-miR-27a is associated with a reduced renal cell cancer risk in a Chinese population.
PloS one - 1 Jan 2012
Shi Danni, Li Pu, Ma Lan, Zhong Dongyan, Chu Haiyan, Yan Fu, Lv Qiang, Qin Chao, Wang Wei, Wang Meilin, Tong Na, Zhang Zhengdong, Yin Changjun
Abstract excerpt
BACKGROUND: MicroRNAs (miRNAs) are a class of small non-coding RNAs to regulate cell differentiation, proliferation, development, and apoptosis. The single nucleotide polymorphism (SNP) rs895819 is located at the terminal loop of pre-miR-27a. Here, we aimed to investigate whether SNP rs895819 was associated with the development of renal cell cancer (RCC) in a Chinese population. METHODS: In this case-control...
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