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Article

Functional polymorphisms in cell death pathway genes and risk of renal cell carcinoma.

Molecular carcinogenesis - 1 Sept 2010

Zhu Jian, Qin Chao, Wang Meilin, Yan Fu, Ju Xiaobing, Meng Xiaoxin, Ding Qi, Li Pu, Yang Jian, Cao Qiang, Zhang Zhengdong, Yin Changjun

Abstract excerpt

The FAS/FAS ligand (FASL) system plays a key role in regulating apoptotic cell death, and corruption of this signaling pathway has been shown to participate in tumorigenesis. However, the effects of functional promoter polymorphisms of the CASP8, FAS, and FASL genes on risk of renal cell carcinoma (RCC) are unknown. In this study, we genotyped CASP8 -652 6N ins/del, FAS -1377 G > A, FAS -670 A > G, and FASL -844...

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Source

Identifiers

PMID: 20572163
DOI: 10.1002/mc.20656

Genes

FAS
CASP8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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