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Article

Identification of somatic mutations in cancer through Bayesian-based analysis of sequenced genome pairs.

BMC genomics - 4 May 2013

Christoforides Alexis, Carpten John D, Weiss Glen J, Demeure Michael J, Von Hoff Daniel D, Craig David W

Abstract excerpt

BACKGROUND: The field of cancer genomics has rapidly adopted next-generation sequencing (NGS) in order to study and characterize malignant tumors with unprecedented resolution. In particular for cancer, one is often trying to identify somatic mutations--changes specific to a tumor and not within an individual's germline. However, false positive and false negative detections often result from lack of sufficient...

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Identifiers

PMID: 23642077
DOI: 10.1186/1471-2164-14-302
PMCID: PMC3751438

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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