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Article

Shimmer: detection of genetic alterations in tumors using next-generation sequence data.

Bioinformatics (Oxford, England) - 15 Jun 2013

Hansen Nancy F, Gartner Jared J, Mei Lan, Samuels Yardena, Mullikin James C

Abstract excerpt

MOTIVATION: Extensive DNA sequencing of tumor and matched normal samples using exome and whole-genome sequencing technologies has enabled the discovery of recurrent genetic alterations in cancer cells, but variability in stromal contamination and subclonal heterogeneity still present a severe challenge to available detection algorithms. RESULTS: Here, we describe publicly available software, Shimmer, which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23620360
DOI: 10.1093/bioinformatics/btt183
PMCID: PMC3673219

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