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Article

Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer.

Nature genetics - 1 Jul 2010

Turnbull Clare, Rapley Elizabeth A, Seal Sheila, Pernet David, Renwick Anthony, Hughes Deborah, Ricketts Michelle, Linger Rachel, Nsengimana Jeremie, Deloukas Panagiotis, Huddart Robert A, Bishop D Timothy, Easton Douglas F, Stratton Michael R, Rahman Nazneen

Abstract excerpt

We conducted a genome-wide association study for testicular germ cell tumor, genotyping 298,782 SNPs in 979 affected individuals and 4,947 controls from the UK and replicating associations in a further 664 cases and 3,456 controls. We identified three new susceptibility loci, two of which include genes that are involved in telomere regulation. We identified two independent signals within the TERT-CLPTM1L locus on...

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Source

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Identifiers

PMID: 20543847
DOI: 10.1038/ng.607
PMCID: PMC3773909

Genes

TERT
DMRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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