Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer.

doi:10.1038/ng.393

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Article

Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer.

Nature genetics - 1 Jul 2009

Kanetsky Peter A, Mitra Nandita, Vardhanabhuti Saran, Li Mingyao, Vaughn David J, Letrero Richard, Ciosek Stephanie L, Doody David R, Smith Lauren M, Weaver Joellen, Albano Anthony, Chen Chu, Starr Jacqueline R, Rader Daniel J, Godwin Andrew K, Reilly Muredach P, Hakonarson Hakon, Schwartz Stephen M, Nathanson Katherine L

Abstract excerpt

Testicular germ cell tumors (TGCT) have been expected to have a strong underlying genetic component. We conducted a genome-wide scan among 277 TGCT cases and 919 controls and found that seven markers at 12p22 within KITLG (c-KIT ligand) reached genome-wide significance (P < 5.0 x 10(-8) in discovery). In independent replication, TGCT risk was increased threefold per copy of the major allele at rs3782179 and...

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Identifiers

PMID: 19483682
DOI: 10.1038/ng.393
PMCID: PMC2865677

Genes

KITLG
SPRY4
KIT

Provenance

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Source receipt: pubmed, retrieved 6 Sept 2026.

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