Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cleft Palate in a Mouse Model of SOX2 Haploinsufficiency.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association - 1 Jan 2014

Langer Lee, Sulik Kathleen, Pevny Larysa

Abstract excerpt

OBJECTIVE: While SEX-determining region Y-Box 2 (SOX2) mutations are typically recognized as yielding ocular and central nervous system abnormalities, they have also been associated with other craniofacial defects. To elucidate the genesis of the latter, Sox2 hypomorphic (Sox2(HYP)) mice were examined, with particular attention to secondary palatal development. RESULTS: Clefts of the secondary palate were found...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Cleft Palate
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to SOX2 gene

Share to Genotype

Share to SOXB1 Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 23638914
DOI: 10.1597/12-260
PMCID: PMC4019342

Genes

SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cleft Palate in a Mouse Model of SOX2 Haploinsufficiency.PMID 23638914Read ↗

Ablation of the Sox11 Gene Results in Clefting of the Secondary Palate Resembling the Pierre Robin Sequence.Semantic proximity Read ↗

Molecular control of secondary palate development.Semantic proximity Read ↗

Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis.Semantic proximity Read ↗

Mice with an anterior cleft of the palate survive neonatal lethality.Semantic proximity Read ↗

<i>Shox2</i>-deficient mice exhibit a rare type of incomplete clefting of the secondary palateSemantic proximity Read ↗

Mesenchymal fibroblast growth factor receptor signaling regulates palatal shelf elevation during secondary palate formation.Semantic proximity Read ↗

A quantitative method for defining high-arched palate using the Tcof1(+/-) mutant mouse as a model.Semantic proximity Read ↗

Analysis of Meox-2 mutant mice reveals a novel postfusion-based cleft palate.Semantic proximity Read ↗

Molecular basis of cleft palates in miceSemantic proximity Read ↗

Tbx22null mice have a submucous cleft palate due to reduced palatal bone formation and also display ankyloglossia and choanal atresia phenotypes.Semantic proximity Read ↗

Secondary cleft palate repair.Semantic proximity Read ↗

Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.