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Article

Mesenchymal fibroblast growth factor receptor signaling regulates palatal shelf elevation during secondary palate formation.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Nov 2015

Yu Kai, Karuppaiah Kannan, Ornitz David M

Abstract excerpt

BACKGROUND: Palatal shelf elevation is an essential morphogenetic process during secondary palate closure and failure or delay of palatal shelf elevation is a common cause of cleft palate, one of the most common birth defects in humans. Here, we studied the role of mesenchymal fibroblast growth factor receptor (FGFR) signaling during palate development by conditional inactivation of Fgfrs using a...

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Identifiers

PMID: 26250517
DOI: 10.1002/dvdy.24319
PMCID: PMC4619180

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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