Article
Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25.
Nature communications - 1 Jan 2011
Nakamura Yukio, Yamamoto Koji, He Xinjun, Otsuki Bungo, Kim Youngwoo, Murao Hiroki, Soeda Tsunemitsu, Tsumaki Noriyuki, Deng Jian Min, Zhang Zhaoping, Behringer Richard R, Crombrugghe Benoit de, Postlethwait John H, Warman Matthew L, Nakamura Takashi, Akiyama Haruhiko
Abstract excerpt
Sox9 is a direct transcriptional activator of cartilage-specific extracellular matrix genes and has essential roles in chondrogenesis. Mutations in or around the SOX9 gene cause campomelic dysplasia or Pierre Robin Sequence. However, Sox9-dependent transcriptional control in chondrogenesis remains largely unknown. Here we identify Wwp2 as a direct target of Sox9. Wwp2 interacts physically with Sox9 and is...
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