Article
Ablation of the Sox11 Gene Results in Clefting of the Secondary Palate Resembling the Pierre Robin Sequence.
The Journal of biological chemistry - 25 Mar 2016
Huang Huarong, Yang Xiaojuan, Bao Meiling, Cao Huanhuan, Miao Xiaoping, Zhang Xiaoyun, Gan Lin, Qiu Mengsheng, Zhang Zunyi
Abstract excerpt
Mouse gene inactivation has shown that the transcription factor Sox11 is required for mouse palatogenesis. However, whether Sox11 is primarily involved in the regulation of palatogenesis still remains elusive. In this study, we explored the role ofSox11in palatogenesis by analyzing the developmental mechanism in cleft palate formation in mutants deficient in Sox11. Sox11 is expressed both in the developing...
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