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Article

Interactions with the Abelson tyrosine kinase reveal compartmentalization of eyes absent function between nucleus and cytoplasm.

Developmental cell - 1 Feb 2009

Xiong Wenjun, Dabbouseh Noura M, Rebay Ilaria

Abstract excerpt

Eyes absent (Eya), named for its role in Drosophila eye development but broadly conserved in metazoa, possesses dual functions as a transcriptional coactivator and protein tyrosine phosphatase. Although Eya's transcriptional activity has been extensively characterized, the physiological requireme...

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Identifiers

PMID: 19217428
DOI: 10.1016/j.devcel.2008.12.005
PMCID: PMC2670569

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19217428-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Interactions with the Abelson tyrosine kinase reveal compartmentalization of eyes absent function between nucleus and cytoplasm.PMID 19217428Read ↗

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The transcription factor Eyes absent is a protein tyrosine phosphatase.Semantic proximity Read ↗

EYA1 phosphatase function is essential to drive breast cancer cell proliferation through cyclin D1.Semantic proximity Read ↗

Using Drosophila to decipher how mutations associated with human branchio-oto-renal syndrome and optical defects compromise the protein tyrosine phosphatase and transcriptional functions of eyes absent.Semantic proximity Read ↗

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