Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

WDR1 is a novel EYA3 substrate and its dephosphorylation induces modifications of the cellular actin cytoskeleton.

Scientific reports - 13 Feb 2018

Mentel Mihaela, Ionescu Aura E, Puscalau-Girtu Ioana, Helm Martin S, Badea Rodica A, Rizzoli Silvio O, Szedlacsek Stefan E

Abstract excerpt

Eyes absent (EYA) proteins are unusual proteins combining in a single polypeptide chain transactivation, threonine phosphatase, and tyrosine phosphatase activities. They play pivotal roles in organogenesis and are involved in a variety of physiological and pathological processes including innate immunity, DNA damage repair or cancer metastasis. The molecular targets of EYA tyrosine phosphatase activity are still...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actin Cytoskeleton
Share to Biocatalysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Conserved Sequence

Share to Microfilament Proteins

Share to Phosphorylation

Share to Protein Domains

Share to Protein Tyrosine Phosphatases

Share to src-Family Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 29440662
DOI: 10.1038/s41598-018-21155-w
PMCID: PMC5811557

Genes

EYA3
EYA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

WDR1 is a novel EYA3 substrate and its dephosphorylation induces modifications of the cellular actin cytoskeleton.PMID 29440662Read ↗

The Eyes Absent proteins in development and in developmental disorders.Semantic proximity Read ↗

EYA1 phosphatase function is essential to drive breast cancer cell proliferation through cyclin D1.Semantic proximity Read ↗

EYA4 drives breast cancer progression and metastasis through its novel role in replication stress avoidance.Semantic proximity Read ↗

Methylation of the phosphatase-transcription activator EYA1 by protein arginine methyltransferase 1: mechanistic, functional, and structural studies.Semantic proximity Read ↗

EYA4, a novel vertebrate gene related to Drosophila eyes absent.Semantic proximity Read ↗

Interactions with the Abelson tyrosine kinase reveal compartmentalization of eyes absent function between nucleus and cytoplasm.Semantic proximity Read ↗

Xeya3 regulates survival and proliferation of neural progenitor cells within the anterior neural plate of Xenopus embryos.Semantic proximity Read ↗

Branchio-oto-renal syndrome associated mutations in Eyes Absent 1 result in loss of phosphatase activity.Semantic proximity Read ↗

Sipl1 and Rbck1 are novel Eya1-binding proteins with a role in craniofacial development.Semantic proximity Read ↗

Functional dissection of eyes absent reveals new modes of regulation within the retinal determination gene network.Semantic proximity Read ↗

Clustering of mutations responsible for branchio-oto-renal (BOR) syndrome in the eyes absent homologous region (eyaHR) of EYA1Semantic proximity Read ↗

Molecular analysis of Drosophila eyes absent mutants reveals features of the conserved Eya domain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.