Cytokine-induced Chromatin Modifications of the Type I Collagen Alpha 2 Gene during Intestinal Endothelial-to-Mesenchymal Transition

Abstract excerpt

BACKGROUND: Fibrosis of the intestine is currently an irreversible complication of inflammatory bowel disease; yet, little is understood of the underlying pathogenesis and antifibrotic strategies remain elusive. To develop effective therapies, knowledge of the mechanism of transcription and excessive deposition of type I collagen, a hallmark of fibrosis, is needed. We have shown previously that...

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