Article
Altered Expression of Angiotensinogen and Mediators of Angiogenesis in Ileal Crohn's Disease.
Journal of gastrointestinal and liver diseases : JGLD - 1 Mar 2016
Hume Georgia E, Doecke James D, Huang Ning, Fowler Elizabeth V, Brown Ian S, Simms Lisa A, Radford-Smith Graham L
Abstract excerpt
BACKGROUND AND AIMS: Angiotensin II (AII) is a powerful splanchnic vasoconstrictor with pro-inflammatory and pro-fibrotic properties. Angiotensin converting enzyme (ACE) inhibitors and AII Receptor Antagonists (ARBs) are therapeutic in animal models of colitis. The aim of this case-control study is to determine the expression of angiotensinogen and related genes in human ileal Crohn's disease. METHODS: Using...
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