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Epigenetic Histone Methylation Modulates Fibrotic Gene Expression

7 Oct 2010

Abstract excerpt

TGF-β1-induced expression of extracellular matrix (ECM) genes plays a major role in the development of chronic renal diseases such as diabetic nephropathy. Although many key transcription factors are known, mechanisms involving the nuclear chromatin that modulate ECM gene expression remain unclear. Here, we examined the role of epigenetic chromatin marks such as histone H3 lysine methylation (H3Kme) in...

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PMID: 20930066
DOI: 10.1681/asn.2010060633

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