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Article

Mutations in protein N-arginine methyltransferases are not the cause of FTLD-FUS.

Neurobiology of aging - 1 Sept 2013

Ravenscroft Thomas A, Baker Matt C, Rutherford Nicola J, Neumann Manuela, Mackenzie Ian R, Josephs Keith A, Boeve Bradley F, Petersen Ronald, Halliday Glenda M, Kril Jillian, van Swieten John C, Seeley William W, Dickson Dennis W, Rademakers Rosa

Abstract excerpt

The nuclear protein fused in sarcoma (FUS) is found in cytoplasmic inclusions in a subset of patients with the neurodegenerative disorder frontotemporal lobar degeneration (FTLD-FUS). FUS contains a methylated arginine-glycine-glycine domain that is required for transport into the nucleus. Recent...

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Source

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Identifiers

PMID: 23635657
DOI: 10.1016/j.neurobiolaging.2013.04.004
PMCID: PMC3683824

Genes

FUS
PRMT1
PRMT3
PRMT8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23635657-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations in protein N-arginine methyltransferases are not the cause of FTLD-FUS.PMID 23635657Read ↗

Arginine methylation by PRMT1 regulates nuclear-cytoplasmic localization and toxicity of FUS/TLS harbouring ALS-linked mutations.Semantic proximity Read ↗

Nuclear import factor transportin and arginine methyltransferase 1 modify FUS neurotoxicity in Drosophila.Semantic proximity Read ↗

Protein arginine methyltransferase 1 and 8 interact with FUS to modify its sub-cellular distribution and toxicity in vitro and in vivo.Semantic proximity Read ↗

Sequestration of PRMT1 and Nd1-L mRNA into ALS-linked FUS mutant R521C-positive aggregates contributes to neurite degeneration upon oxidative stress.Semantic proximity Read ↗

Transportin 1 accumulates specifically with FET proteins but no other transportin cargos in FTLD-FUS and is absent in FUS inclusions in ALS with FUS mutations.Semantic proximity Read ↗

Heterogeneous nuclear ribonucleoproteins R and Q accumulate in pathological inclusions in FTLD-FUSSemantic proximity Read ↗

Altered Tau Isoform Ratio Caused by Loss of FUS and SFPQ Function Leads to FTLD-like Phenotypes.Semantic proximity Read ↗

Mutations in the 3' untranslated region of FUS causing FUS overexpression are associated with amyotrophic lateral sclerosis.Semantic proximity Read ↗

Mutated FUS in familial amyotrophic lateral sclerosis involves multiple hnRNPs in the formation of neuronal cytoplasmic inclusions.Semantic proximity Read ↗

Pathology of three ALS patients with FUS variants, including one likely benign Q23L variant lacking FUS inclusions.Semantic proximity Read ↗

Proximity-based labeling reveals DNA damage-induced phosphorylation of fused in sarcoma (FUS) causes distinct changes in the FUS protein interactome.Semantic proximity Read ↗

A new subtype of frontotemporal lobar degeneration with FUS pathology.Semantic proximity Read ↗

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